EFFECT OF DUAL-TRACK INTERACTIVE NURSING INTERVENTION MODEL ON ANXIETY AND DEPRESSION IN PATIENTS WITH CORONARY HEART DISEASE

Background: Elderly patients with coronary heart disease often suffer adverse psychological reactions, such as anxiety and depression. The dual-track interactive nursing model is a nursing intervention aimed to provide specific and community nursing. For patients with chronic diseases, this model can improve the patients’ self-management and rehabilitation. The effect of this model on the mental health of patients with chronic diseases has been unanimously recognized by researchers. In this study, a dual-track interactive nursing model intervention was conducted on the anxiety and depression in elderly patients with coronary heart disease to verify the psychological effect of the model. Subjects and methods: From June 2018 to June 2019, 136 elderly patients with coronary heart disease (mean age of 63.5±8.26 years) from three communities in Changsha, Hunan Province, China were selected as subjects. A total of 53 and 50 patients were identified in the intervention and the control groups, respectively. The control group underwent routine longitudinal referral, whereas the intervention group was subjected to a two-track interactive nursing model intervention. The Short Form-36 Health Survey (SF-36) and related questionnaires were used to monitor and compare the two groups before and after the intervention and employed for scoring and comparative analysis. Results: After the intervention, the mental health scores of the intervention group in total score, somatization, obsessive–compulsive symptoms, interpersonal sensitivity, depression, anxiety, hostility, and paranoia are significantly lower than those of the control group (P<0.05). The intervention group has scored significantly higher in coping style but significantly lower in negative coping than the control group (P<0.05). Conclusions: The application of the dual-track interactive nursing model intervention in the management of patients with coronary heart disease can improve the self-management and the mental health of patients with coronary heart disease

An observer-based type-3 fuzzy control for non-holonomic wheeled robots

Non-holonomic wheeled robots (NWR) comprise a type of robotic system; they use wheels for movement and offer several advantages over other types. They are efficient, highly, and maneuverable, making them ideal for factory automation, logistics, transportation, and healthcare. The control of this type of robot is complicated, due to the complexity of modeling, asymmetrical non-holonomic constraints, and unknown perturbations in various applications. Therefore, in this study, a novel type-3 (T3) fuzzy logic system (FLS)-based controller is developed for NWRs. T3-FLSs are employed for modeling, and the modeling errors are considered in stability analysis based on the symmetric Lyapunov function. An observer is designed to detect the error, and its effect is eliminated by a developed terminal sliding mode controller (SMC). The designed technique is used to control a case-study NWR, and the results demonstrate the good accuracy of the developed scheme under non-holonomic constraints, unknown dynamics, and nonlinear disturbances

YNU_OXZ @ HaSpeeDe 2 and AMI : XLM-RoBERTa with Ordered Neurons LSTM for classification task at EVALITA 2020

This paper describes the system that team YNU_OXZ submitted for EVALITA 2020. We participate in the shared task on Automatic Misogyny Identification (AMI) and Hate Speech Detection (HaSpeeDe 2) at the 7th evaluation campaign EVALITA 2020. For HaSpeeDe 2, we participate in Task A - Hate Speech Detection and submitted two-run results for the news headline test and tweets headline test, respectively. Our submitted run is based on the pre-trained multi-language model XLM-RoBERTa, and input into Convolution Neural Network and K-max Pooling (CNN + K-max Pooling). Then, an Ordered Neurons LSTM (ON-LSTM) is added to the previous representation and submitted to a linear decision function. Regarding the AMI shared task for the automatic identification of misogynous content in the Italian language. We participate in subtask A about Misogyny & Aggressive Behaviour Identification. Our system is similar to the one defined for HaSpeeDe and is based on the pre-trained multi-language model XLM-RoBERTa, an Ordered Neurons LSTM (ON-LSTM), a Capsule Network, and a final classifier

An Ensemble Multilabel Classification for Disease Risk Prediction

It is important to identify and prevent disease risk as early as possible through regular physical examinations. We formulate the disease risk prediction into a multilabel classification problem. A novel Ensemble Label Power-set Pruned datasets Joint Decomposition (ELPPJD) method is proposed in this work. First, we transform the multilabel classification into a multiclass classification. Then, we propose the pruned datasets and joint decomposition methods to deal with the imbalance learning problem. Two strategies size balanced (SB) and label similarity (LS) are designed to decompose the training dataset. In the experiments, the dataset is from the real physical examination records. We contrast the performance of the ELPPJD method with two different decomposition strategies. Moreover, the comparison between ELPPJD and the classic multilabel classification methods RAkEL and HOMER is carried out. The experimental results show that the ELPPJD method with label similarity strategy has outstanding performance

Reflections on Literature : East and West

This publication has three thematic essays written by professors from Pace University and Nanjing Normal University that discuss the similarities and differences between Chinese and western literature. Hongling Lyu identifies certain aesthetic differences between Chinese and western literature, and explains these divergences from a cross-cultural perspective. Li Po presents an overview of the aesthetics of classical literature. Ying Wang draws on her expertise in French literature and feminist studies to discuss the challenge of reading Chinese literature from the historical, cross-cultural, and feminist perspectives. These essays challenge us to go beyond the conventional East-and-West divide with its predictable polarities, and gives us a feasible framework to evaluate the evolution of Chinese literature in the modern era

Deformation rule of bored pile & steel support for deep foundation pit in sandy pebble geology

Regarding the whole&nbsp;excavation process of the support system of the Southwest Jiaotong University Station of Chengdu Metro Line 6 (the deep foundation pit bored pile + steel support and support system) as the engineering background, this paper studies the deformation rule of the deep foundation pit bored pile + steel support of the sandy pebble foundation. The deformation rule of this support system, the settlement rule of the ground surface outside the pit, and the rule of the uplift of the loose&nbsp;at the bottom of the pit are studied. A key analysis of the positive corner of the foundation pit is conducted, and the rationality of the optimization of the support scheme is evaluated. This paper provides effective guidance for the subsequent deep foundation pit construction and provides a reference for deep foundation pit construction

Effect of regenerator on the direct steam generation solar power system characterized by prolonged thermal storage and stable power conversion

The direct steam generation (DSG) solar power system using two stage accumulators and cascade steam-organic Rankine cycle (RC-ORC) has remarkably enlarged storage capacity. It can facilitate stable power generation and address the challenges of conventional DSG systems. Regenerator is generally an issue worthy of discussion in organic Rankine cycle (ORC) systems. However, its influence on the newly proposed DSG system has not been investigated yet and is expected to be appreciable. Introducing a regenerator affects not only the ORC efficiency, RC-ORC efficiency, heat exchanger area, but also heat storage capacity, discharge duration, discharge efficiency, aperture area of collectors and the net profit (ΔP). Detailed performance comparison between the DSG systems without/with regenerator is carried out in this paper. The results indicate that at a given power output, aperture area is reduced by the regenerator especially for MM, R365mfc and pentane due to the increment in ORC, RC-ORC and discharge efficiencies, as well as the decrement in heat input. Discharge duration is shortened by 0.01–1.78 h depending on ORC fluids. R365mfc exhibits the maximum ΔP (4.19∼6.48 million USD), followed by MM and pentane. On the contrary, ΔP is negative for benzene (−5.61∼-4.31 million USD)

New tumor-targeted nanosized delivery carrier for oligonucleotides: characteristics in vitro and in vivo

Tianyang Zhou1,2, Xin Jia1, Huixiang Li3, Jin Wang3, Hongling Zhang1,2, Youmei A1,2, Zhenzhong Zhang1,21School of Pharmaceutical Sciences, 2Nanotechnology Research Center for Drugs, 3Department of Pathology, Medical School of Zhengzhou University, Zhengzhou, People&amp;rsquo;s Republic of ChinaBackground: The purpose of this study was to investigate the in vitro and in vivo characteristics of a new tumor-targeted nanosized delivery carrier for antisense oligonucleotide (ASON).Methods: Polyethylenimine (PEI) was used to condense ASON to form nanosized complexes (PEI/ASON), which were then modified using asparagine-glycine-arginine (NGR) peptide to obtain a tumor-targeted nanosized delivery carrier (NGR/PEI/ASON). The conditions required to form PEI/ASON were investigated.Results: A linear correlation between the natural logarithm of the N/P ratio (PEI to ASON) and the zeta potential of the PEI/ASON complexes was found, ranging from 1.5 to 5.0. The pH of the solution strongly influenced the zeta potential of the PEI/ASON complexes. PEI/ASON and NGR/PEI/ASON were stable in RPMI-1640 culture medium in the presence of Dextran 70. Incorporation of ASON into PEI/ASON and NGR/PEI/ASON complexes prevented degradation of ASON by DNase I.Conclusion: Both ASON/PEI and NGR/PEI/ASON complexes enhanced the uptake of ASON by EC9706 cells in vitro. In vivo, NGR/PEI/ASON complexes had the ability to target tumor tissues effectively.Keywords: nanosized delivery system, squamous cell carcinoma, antisense oligonucleotid

miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells

AbstractMesenchymal stem cells (MSCs) can differentiate into several distinct cell types, including osteoblasts and adipocytes. The balance between osteogenic and adipogenic differentiation is disrupted in several osteogenic-related disorders, such as osteoporosis. So far, little is known about the molecular mechanisms that drive final lineage commitment of MSCs. In this study, we revealed that miR-17-5p and miR-106a have dual functions in the modulation of human adipose-derived mesenchymal stem cells (hADSCs) commitment by gain- and loss-of-function assays. They could promote adipogenesis and inhibit osteogenesis. Luciferase reporter assay, western blot and ELISA suggested BMP2 was a direct target of miR-17-5p and miR-106a. Downregulation of endogeneous BMP2 by RNA interference suppressed osteogenesis and increased adipogenesis, similar to the effect of miR-17-5p and miR-106a upregulation. Moreover, the inhibitory effects of miR-17-5p on osteogenic and adipogenic differentiation of hADSCs could be reversed by BMP2 RNA interference. In conclusion, miR-17-5p and miR-106a regulate osteogenic and adipogenic lineage commitment of hADSCs by directly targeting BMP2, and subsequently decreased osteogenic TAZ, MSX2 and Runx2, and increased adipogenic C/EBPα and PPARγ